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hdac: The many roles of histone deacetylases in development and ... - Nature,Erasers of Histone Acetylation: The Histone Deacetylase Enzymes,Anticancer Therapy with HDAC Inhibitors: Mechanism-Based Combination ...,The role of HDAC3 and its inhibitors in regulation of ... - Nature,
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The many roles of histone deacetylases in development and ... - Nature
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Erasers of Histone Acetylation: The Histone Deacetylase Enzymes
Histone deacetylases (HDACs) catalyze the removal of acetyl groups from lysine residues at the amino termini of histones. Because this action causes chromatin to condense into a transcriptionally repressed conformation, HDACs are mainly involved in gene silencing [ 2 - 4 ].
Anticancer Therapy with HDAC Inhibitors: Mechanism-Based Combination ...
Histone deacetylase (HDAC) serves as a critical molecular regulator in the pathobiology of various malignancies and have garnered attention as a viable target for therapeutic intervention. A variety of HDAC inhibitors (HDACis) have been developed to target HDACs. Many preclinical studies have conclusively demonstrated the antitumor effects of HDACis, whether used as monotherapy or in ...
The role of HDAC3 and its inhibitors in regulation of ... - Nature
Histone deacetylase inhibitors (HDACi) are already approved for the therapy of leukemias. Since they are also emerging candidate compounds for the treatment of non-malignant diseases, HDACi with a wide therapeutic window and low hazard potential are desirable.
